Wearable data collection devices (Garmin Wearables, Apple Watch, etc.) provide opportunities to collect real-time data from clinical research subjects. This can include physiological measurements like heart rate and Pulse Oxymetry and behavioral measurements like steps taken, stairs climbed, minutes slept. But the opportunity presents uncertainties: What’s the quality of the sensors and collected data? Is there data security? Is the data provided in a HIPAA compliant manner? What about publicly available data, like Strava, can that be aggregated and used as clinical trial data? In this forum, we’ll discuss the opportunities presented by wearables, the regulatory rules of the road, and effective approaches to take. We will also hear from Boston Children’s Hospital about their program using Amazon's voice assistant Alexa to enable parents and caregivers to provide clinicians with updates on their progress after surgery and get information on post-operative appointments.