Add to Calendar 5/16/2019 8:00:00 AM 5/16/2019 10:00:00 AM Exploration of Non-traditional Therapeutics: Antibody Drug Conjugates
With over 30 years of R&D history, Antibody-drug Conjugates combine the targeting capabilities of monoclonal antibodies with the cancer-killing ability of cytotoxic drugs. Their goal is to transport “deactivated” toxic agents to targeted cancer cells without adversely affecting normal tissues. Once in the tumor cell the cytotoxin’s full cancer killing capability is activated causing rapid cell death. Although it sounds simple these therapies are complex and throughout its history and ongoing research is focused on optimizing the components and the resultant whole in terms of its ability to target the right cells and deliver the most effective knockout punch to cancer cells.
Our distinguished panel of experts will cover:
  • Why ADCs?
  • Latest ADC approaches to speed component selection and testing
  • Modern techniques to ensure stability, targeted delivery, and limited off-target effects
  • Working with FDA to create a joint understanding of how their therapies work and accelerate time to clinical trials
  • Where are we going? The application of ADCs beyond oncology and hematology to other important disease areas
NOTE: This forum will be held at the Ragon Institute Auditorium, 400 Technology Square which is adjacent to the MassBio offices which are at 300 Technology Square.
Ragon Auditorium, 400 Tech Square, Cambridge, MA 02139
Executive Vice President and Chief Scientific Officer, Immunogen
Dr. Gregory received his Ph.D. in Biochemistry from the University of Massachusetts at Amherst in 1986, followed by post-doctoral research in cancer genetics at the Worcester Foundation for Experimental Biology in Shrewsbury MA. In 1989 he joined Genzyme Corporation, where he was responsible for discovery projects in the molecular biology department. In 1990, his group at Genzyme was the first to express the cystic fibrosis transmembrane conductance regulator (CFTR) protein and to determine the molecular defect caused by the most common mutation of CFTR. In 2003 Richard became Senior Vice President and Head of Research for Genzyme Corporation where he was responsible for early R&D, from discovery to development, in all therapeutic areas at Genzyme. In 2011, following the acquisition of Genzyme by Sanofi, Richard was appointed Head of the Sanofi Genzyme R&D Center, overseeing R&D in rare diseases, multiple sclerosis, immune disorders and tissue protection/regenerative medicine. In January of 2015 Dr. Gregory joined ImmunoGen, where he oversees research leading to new antibody based therapeutics to address the unmet needs of patients with cancer. He is the co-author of over 60 peer-reviewed publications and 23 issued U.S. patents in the area of biotechnology. Richard is a Fellow of the American Institute for Medical and Biological Engineering.