PROTACs - Targeted Protein Degradation: Promises and Challenges Ahead

September 29, 2020 12:00 PM - 1:00 PM

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Add to Calendar 9/29/2020 12:00:00 PM 9/29/2020 1:00:00 PM PROTACs - Targeted Protein Degradation: Promises and Challenges Ahead Targeted protein degradation is an emerging therapeutic modality which has made tremendous progress and attracted massive investment in recent years. This modality is a class of bifunctional small molecules composed of an E3 ligase binder linked to a target protein binding moiety. It offers the possibility to degrade any intracellular target proteins regardless if there is a well-defined binding pocket in the target protein. Therefore, it opens numerous opportunities to drug many previously unreachable targets. However, the molecules tend to be bulky, floppy, greasy, and lack drug likeness properties. Nevertheless, increasing preclinical animal data has demonstrated the desired efficacy. Very recently, the early clinical safety and PK results are encouraging. In this forum our expert panel will share key learnings about this novel modality and discuss strategies to overcome potential challenges ahead.

Sponsored by MassBio's Drug Discovery forum working group.


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Vice President Of Preclinical Development, Kymera Therapeutics
Haojing Rong is the Vice President of Preclinical Development at Kymera Therapeutics. She earned her Ph.D. at Faculty of Pharmaceutical Science of Ghent University in Belgium. Haojing started her career in the DMPK area at Amgen, Thousand Oaks, CA, followed by experiences at several large and small companies such as Merck, Amira Pharmaceuticals, and Pfizer Groton and Cambridge. She was a Director of Nonclinical Development at Shire prior to joining Kymera in 2018. Haojing’s interest and expertise include ADME and Tox knowledge integration for both small molecule and biotherapeutics, prediction of human pharmacokinetics, drug interactions using modeling and simulation, and applying integrated PK/PD modeling approach for both efficacy and safety for drug development.